Abiraterone acetate tablets are taken orally once daily according to the applicable prescribing regimen. Current U.S. labeling requires administration on an empty stomach: patients should not eat for 2 hours before or 1 hour after taking the tablets.
Food requirements
Food can substantially increase abiraterone exposure. For this reason, the tablets must not be taken with meals. European product information likewise states that the medicine must not be taken with food.
How the tablets are administered
- Take the prescribed daily dose exactly as directed.
- Take the tablets on an empty stomach.
- Swallow tablets whole with water.
- Do not crush or chew tablets.
- Take the medicine at approximately the same time each day when practical.
- Do not independently change the dose.
Corticosteroid treatment
Abiraterone treatment is used with prednisone or prednisolone according to the applicable indication and labeling. Patients should not independently alter or discontinue corticosteroid therapy because steroid withdrawal or inadequate corticosteroid coverage can create clinically important problems.
Androgen-deprivation therapy
Current U.S. labeling states that patients receiving abiraterone should also receive a GnRH analog or should have undergone bilateral orchiectomy.
Missed dose
If abiraterone or the accompanying prednisone/prednisolone dose is missed, current U.S. product information advises contacting the treating healthcare professional for instructions rather than taking an unscheduled extra dose.
Storage
Storage requirements should be taken from the specific Abirapro packaging and official product documentation. Product-specific storage information is [Information requires verification].